Accelerating Precision Drug Development and Drug Repurposing by Leveraging Human Genetics - Biowebspin | Biowebspin
Accelerating Precision Drug Development and Drug Repurposing by Leveraging Human Genetics

Accelerating Precision Drug Development and Drug Repurposing by Leveraging Human Genetics

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  Biowebspin, April 12th, 2017

Accelerating Precision Drug Development and Drug Repurposing by Leveraging Human Genetics

by Jill M. Pulley, Jana K. Shirey-Rice, Robert R. Lavieri, Rebecca N. Jerome, Nicole M. Zaleski, David M. Aronoff, Lisa Bastarache, Xinnan Niu, Kenneth J. Holroyd, Dan M. Roden, Eric P. Skaar, Colleen M. Niswender, Lawrence J. Marnett, Craig W. Lindsley, Leeland B. Ekstrom, Alan R. Bentley, Gordon R. Bernard, Charles C. Hong and Joshua C. Denny, in ASSAY and Drug Development Technologies, 2017

The potential impact of using human genetic data linked to longitudinal electronic medical records on drug development is extraordinary; however, the practical application of these data necessitates some organizational innovations. Vanderbilt has created resources such as an easily queried database of >2.6 million de-identified electronic health records linked to BioVU, which is a DNA biobank with more than 230,000 unique samples. To ensure these data are used to maximally benefit and accelerate both de novo drug discovery and drug repurposing efforts, we created the Accelerating Drug Development and Repurposing Incubator, a multidisciplinary think tank of experts in various therapeutic areas within both basic and clinical science as well as experts in legal, business, and other operational domains. The Incubator supports a diverse pipeline of drug indication finding projects, leveraging the natural experiment of human genetics.

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