Identification of validated targets, small molecules or phenotypic screening for the treatment of NASH (Non-alcoholic steatohepatitis) - Biowebspin | Biowebspin
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External open innovation partner programIdentification of validated targets, small molecules or phenotypic screening for the treatment of NASH (Non-alcoholic steatohepatitis)

Have you identified new validated targets, small molecules or phenotypic screening for the treatment of NASH (Non-alcoholic steatohepatitis)? Are you interested in partnering with Akros Pharma Inc. and Japan Tobacco Pharmaceutical Division to translate your new science into a new medicine?

What we are looking for

For the treatment of NASH, we are looking for:

  • Drug targets: newly identified, druggable (tractable with small chemical compounds), disease-relevant (validated with a series of studies) targets
  • Hit / Lead compounds: small chemical compounds which show desirable activity on a) novel drug targets or b) known targets for which no small chemical compounds have been identified
  • Phenotypic screening systems - newly established, disease-relevant (in the cell origin, cell functions, stimuli, culture conditions, readouts), high throughput screening-compatible cell culture systems

We are interested in research programs which may lead to the development of drugs that fulfill the following target product profile (TPP):

  • a) orally active, first-in-class small chemical entities,
  • b) satisfy the unmet medical needs with a clear advantage over the current therapy,
  • c)reduce NAFLD activity score or improve NAFLD fibrosis score

We are not interested in:

  • Any modalities other than small chemical compounds
  • Common mechanisms of fibrotic diseases (not liver-specific)
  • Drug targets not accompanied by validation of disease relevance
  • Undruggable targets
  • Drug targets which have a risk of safety issues when systemically modulated
  • Drug targets with known small chemical drugs
  • Phenotypic screening systems not accompanied by validation of disease relevance
What we offer & How does it work

All proposals will be assessed by our Research &Development team. Based on the level of interest within the Company research portfolio and strategic fit, we will enter into discussion with selected candidate(s), potentially leading to partnership agreements or collaborations.

Proponents that submit proposals of interest will be contacted within 8 weeks of submission to clarify additional details.

What to submit

Submit a proposal in a form which is available online (it takes about 15 minutes).The proposal should be brief, sufficient to provide the main body of the proposal and its innovativeness. The applicant should also provide information about his or her critical knowledge that is applicable for the project, and how the knowledge could be supplemented (i.e., what is additionally required to complete the project). The applicants are strongly encouraged to give us additional information including references or other materials to facilitate the evaluation process.

Privacy, confidentiality & FAQ
The company

The Company will not share the information beyond its own staff; your initial proposal should contain only non-confidential information.
If your proposal is selected, the Company is open to complete a Confidentiality Disclosure Agreement (CDA).

Biowebspin

Biowebspin pays a lot of attention to the privacy, intellectual property, confidentiality and security of its member data. Biowebspin is a matchmaking platform between academia & industry. Biowebspin is not involved in the IP discussion and is not charging any success or license fees. Your «Open Innovation» proposal on Biowebspin are only visible by industrials and the Biowebspin team. You can remove your data at any time. Biowebspin strongly recommends that you do not enter any confidential data or if you do so, that your technology transfer office agrees the submission of your pre-proposal on Biowebspin. If you directly submit your pre-proposal on an industrial partner website, you will agree their terms, conditions and privacy policy of our industrial partner website. Biowebspin is not responsible for the content, accuracy, or opinion of its industrial partner website. As a Swiss International company, Biowebspin has high standard security and privacy system. Biowebspin is in accordance with the Federal Data Protection and Information Commissioner. Check here the terms and conditions of the matchmaking service of Biowebspin.

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