Innovation Management? Orienting Sepsis R&D and Technology Transfer Towards Stratified Medicine - Biowebspin | Biowebspin
Innovation Management? Orienting Sepsis R&D and Technology Transfer Towards Stratified Medicine

Innovation Management? Orienting Sepsis R&D and Technology Transfer Towards Stratified Medicine

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  Biowebspin, April 18th, 2016

Innovation Management? Orienting Sepsis R&D and Technology Transfer Towards Stratified Medicine

by Vural Özdemir, Nezih Hekim, in EBioMedicine, 2016

The Third International Consensus Definitions Task Force has recently defined sepsis as a “life-threatening organ dysfunction due to a dysregulated host response to infection” (Singer et al., 2016). This broad framework is a clear advancement over multiple, inconsistent and narrow definitions employed in the past that tended to focus on infection or pro-inflammatory processes alone. Pro- and anti-inflammatory signaling occur simultaneously in host response to infection. Hence, we need in the current era a holistic and systems approach to decipher the large interindividual and between-population variability in pathogenesis of sepsis (Bauer et al., 2016 and Wong et al., 2014).

Biomarkers that rapidly establish diagnosis and prognosis early in the course of sepsis are of particular interest for proactive interventions. Yet, the existing biomarker or diagnostic candidates fall quite short of the desired clinical sensitivity and specificity (Sims et al., 2016). There is no “typical” sepsis patient, nor a “universal therapy”, given that sepsis is a complex syndrome driven by host-environment interactions. Moreover, that many of the clinical trials aimed at novel sepsis diagnostics and therapeutics have failed is attributable, in part, to such hitherto unaccounted host, infectious agent and environmental heterogeneity enacting on each patient. Had we conducted clinical trials that were better characterized for patient-to-patient variations in molecular etiologies and host responses, we would have been perhaps better poised to diagnose and prognosticate sepsis and its divergent outcomes (Sims et al., 2016 and Özdemir et al., 2015b).

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